GrippeCanadaV3, Main, Exploration, bibRecord, 000088

Pre-and post-pandemic trends in antiviral use in hospitalized patients with laboratory-confirmed influenza: 2004/05-2013/14, Toronto, Canada.

Identifieur interne : 000088 ( Main/Exploration ); précédent : 000087; suivant : 000089

Pre-and post-pandemic trends in antiviral use in hospitalized patients with laboratory-confirmed influenza: 2004/05-2013/14, Toronto, Canada.

Auteurs : Brenda L. Coleman [Canada] ; Kazi Hassan [Canada] ; Karen Green [Canada] ; Jonathan B. Gubbay [Canada] ; Kevin Katz [Canada] ; Tony Mazzulli [Canada] ; Shelly Mcneil [Canada] ; Matthew Muller [Canada] ; Jeff Powis [Canada] ; David Richardson [Canada] ; Andrew Simor [Canada] ; Allison J. Mcgeer [Canada]

Source :

Antiviral research [ 1872-9096 ] ; 2017.

RBID : pubmed:28179155

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Antiviraux (usage thérapeutique), Canada (épidémiologie), Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Grippe humaine (diagnostic), Grippe humaine (traitement médicamenteux), Grippe humaine (virologie), Grippe humaine (épidémiologie), Hospitalisation, Humains, Jeune adulte, Modèles logistiques, Mâle, Pandémies, Saisons, Sous-type H1N1 du virus de la grippe A (isolement et purification), Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes, Études rétrospectives.
MESH :
- diagnostic : Grippe humaine.
- isolement et purification : Sous-type H1N1 du virus de la grippe A.
- traitement médicamenteux : Grippe humaine.
- usage thérapeutique : Antiviraux.
- virologie : Grippe humaine.
- épidémiologie : Canada, Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Hospitalisation, Humains, Jeune adulte, Modèles logistiques, Mâle, Pandémies, Saisons, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes, Études rétrospectives.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antiviral Agents (therapeutic use), Canada (epidemiology), Child, Child, Preschool, Cohort Studies, Female, Hospitalization, Humans, Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (diagnosis), Influenza, Human (drug therapy), Influenza, Human (epidemiology), Influenza, Human (virology), Logistic Models, Male, Middle Aged, Pandemics, Retrospective Studies, Risk Factors, Seasons, Young Adult.
MESH :
- chemical , therapeutic use : Antiviral Agents.
- diagnosis : Influenza, Human.
- drug therapy : Influenza, Human.
- epidemiology : Canada, Influenza, Human.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Cohort Studies, Female, Hospitalization, Humans, Logistic Models, Male, Middle Aged, Pandemics, Retrospective Studies, Risk Factors, Seasons, Young Adult.

Abstract

BACKGROUND

Data on factors associated with the use of antiviral medication to treat influenza in both children and adults are limited.

OBJECTIVES

To describe trends in antiviral use, analyze factors associated with antiviral treatment of hospitalized patients with influenza, and to compare use based on guidelines.

STUDY DESIGN

A retrospective observational cohort of hospitalized patients with laboratory confirmed influenza in southern Ontario hospitals for the 2004/05-2013/14 seasons.

RESULTS

Of the 7967 patients, 18% of the 1779 children (<15 years) and 66% of the 6188 adults received antiviral therapy. The percentage treated increased from 29% pre-pandemic to 74% during the pandemic, decreased to 55% in 2011/12 and then increased to 65% in 2013/14. Factors significantly associated with antiviral prescription across all age groups during the non-pandemic seasons include influenza type, disease severity, interval between symptom onset and test sample submission, and clinician suspicion of influenza. Rate of treatment of patients meeting guideline criteria was low for children and moderate for adults.

CONCLUSIONS

Since the pandemic, there has been a sustained increase in the use of antiviral medication for all age groups of hospitalized patients with influenza, but much higher for adults than children. The odds of treatment are higher for patients with more severe disease as well as for those tested within 48 h of symptom onset, both of which are part of the guidelines for treatment with anti-influenza medications.

DOI: 10.1016/j.antiviral.2017.01.025
PubMed: 28179155

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000106
to stream Main, to step Curation: 000106

Le document en format XML

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<country xml:lang="fr">Canada</country>
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<author><name sortKey="Powis, Jeff" sort="Powis, Jeff" uniqKey="Powis J" first="Jeff" last="Powis">Jeff Powis</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Michael Garron Hospital, 825 Coxwell Ave., East York, ON M4C3E7, Canada; William Osler Health System, 2100 Bovaird Dr. E., Brampton, ON L6R3J7</wicri:regionArea>
<wicri:noRegion>ON L6R3J7</wicri:noRegion>
</affiliation>
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<author><name sortKey="Richardson, David" sort="Richardson, David" uniqKey="Richardson D" first="David" last="Richardson">David Richardson</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>William Osler Health System, 2100 Bovaird Dr. E., Brampton, ON L6R3J7</wicri:regionArea>
<wicri:noRegion>ON L6R3J7</wicri:noRegion>
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<author><name sortKey="Simor, Andrew" sort="Simor, Andrew" uniqKey="Simor A" first="Andrew" last="Simor">Andrew Simor</name>
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<country xml:lang="fr">Canada</country>
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<term>Adult</term>
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<term>Aged, 80 and over</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Canada (epidemiology)</term>
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<term>Child, Preschool</term>
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<term>Female</term>
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<term>Influenza, Human (diagnosis)</term>
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<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (virology)</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Seasons</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Canada (épidémiologie)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Grippe humaine (diagnostic)</term>
<term>Grippe humaine (traitement médicamenteux)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Jeune adulte</term>
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<term>Mâle</term>
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<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études de cohortes</term>
<term>Études rétrospectives</term>
</keywords>
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</keywords>
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<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Canada</term>
<term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Seasons</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Saisons</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études de cohortes</term>
<term>Études rétrospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Data on factors associated with the use of antiviral medication to treat influenza in both children and adults are limited.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>To describe trends in antiviral use, analyze factors associated with antiviral treatment of hospitalized patients with influenza, and to compare use based on guidelines.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>STUDY DESIGN</b>
</p>
<p>A retrospective observational cohort of hospitalized patients with laboratory confirmed influenza in southern Ontario hospitals for the 2004/05-2013/14 seasons.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Of the 7967 patients, 18% of the 1779 children (<15 years) and 66% of the 6188 adults received antiviral therapy. The percentage treated increased from 29% pre-pandemic to 74% during the pandemic, decreased to 55% in 2011/12 and then increased to 65% in 2013/14. Factors significantly associated with antiviral prescription across all age groups during the non-pandemic seasons include influenza type, disease severity, interval between symptom onset and test sample submission, and clinician suspicion of influenza. Rate of treatment of patients meeting guideline criteria was low for children and moderate for adults.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Since the pandemic, there has been a sustained increase in the use of antiviral medication for all age groups of hospitalized patients with influenza, but much higher for adults than children. The odds of treatment are higher for patients with more severe disease as well as for those tested within 48 h of symptom onset, both of which are part of the guidelines for treatment with anti-influenza medications.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28179155</PMID>
<DateCompleted><Year>2017</Year>
<Month>12</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>02</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-9096</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>140</Volume>
<PubDate><Year>2017</Year>
<Month>04</Month>
</PubDate>
</JournalIssue>
<Title>Antiviral research</Title>
<ISOAbbreviation>Antiviral Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Pre-and post-pandemic trends in antiviral use in hospitalized patients with laboratory-confirmed influenza: 2004/05-2013/14, Toronto, Canada.</ArticleTitle>
<Pagination><MedlinePgn>158-163</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0166-3542(16)30612-X</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.antiviral.2017.01.025</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Data on factors associated with the use of antiviral medication to treat influenza in both children and adults are limited.</AbstractText>
<AbstractText Label="OBJECTIVES">To describe trends in antiviral use, analyze factors associated with antiviral treatment of hospitalized patients with influenza, and to compare use based on guidelines.</AbstractText>
<AbstractText Label="STUDY DESIGN">A retrospective observational cohort of hospitalized patients with laboratory confirmed influenza in southern Ontario hospitals for the 2004/05-2013/14 seasons.</AbstractText>
<AbstractText Label="RESULTS">Of the 7967 patients, 18% of the 1779 children (<15 years) and 66% of the 6188 adults received antiviral therapy. The percentage treated increased from 29% pre-pandemic to 74% during the pandemic, decreased to 55% in 2011/12 and then increased to 65% in 2013/14. Factors significantly associated with antiviral prescription across all age groups during the non-pandemic seasons include influenza type, disease severity, interval between symptom onset and test sample submission, and clinician suspicion of influenza. Rate of treatment of patients meeting guideline criteria was low for children and moderate for adults.</AbstractText>
<AbstractText Label="CONCLUSIONS">Since the pandemic, there has been a sustained increase in the use of antiviral medication for all age groups of hospitalized patients with influenza, but much higher for adults than children. The odds of treatment are higher for patients with more severe disease as well as for those tested within 48 h of symptom onset, both of which are part of the guidelines for treatment with anti-influenza medications.</AbstractText>
<CopyrightInformation>Copyright © 2017 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Coleman</LastName>
<ForeName>Brenda L</ForeName>
<Initials>BL</Initials>
<AffiliationInfo><Affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada. Electronic address: Brenda.coleman@sinaihealthsystem.ca.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hassan</LastName>
<ForeName>Kazi</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Green</LastName>
<ForeName>Karen</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gubbay</LastName>
<ForeName>Jonathan B</ForeName>
<Initials>JB</Initials>
<AffiliationInfo><Affiliation>Public Health Ontario Laboratories, 661 University Ave., Toronto, ON M5G1M1, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Katz</LastName>
<ForeName>Kevin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>North York General Hospital, 4001 Leslie St., North York, ON M2K1E1, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mazzulli</LastName>
<ForeName>Tony</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McNeil</LastName>
<ForeName>Shelly</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Canadian Centre for Vaccinology, IWK Health Centre, 5850/5980 University Ave., Halifax, NS B3K6R8, Canada; Dalhousie University, 6299 South St, Halifax, NS B3H4R2, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Muller</LastName>
<ForeName>Matthew</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>St. Michael's Hospital, 30 Bond St., Toronto, ON M5B1W8, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Powis</LastName>
<ForeName>Jeff</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Michael Garron Hospital, 825 Coxwell Ave., East York, ON M4C3E7, Canada; William Osler Health System, 2100 Bovaird Dr. E., Brampton, ON L6R3J7, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Richardson</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>William Osler Health System, 2100 Bovaird Dr. E., Brampton, ON L6R3J7, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Simor</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Toronto, ON M4N3M5, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>TIBDN</CollectiveName>
</Author>
<Author ValidYN="Y"><LastName>McGeer</LastName>
<ForeName>Allison J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>Sinai Health System, 600 University Avenue, Toronto, ON M5G1X5, Canada; University of Toronto, 155 College Street, Toronto, ON M5T3M7, Canada.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><Agency>CIHR</Agency>
<Country>Canada</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>02</Month>
<Day>06</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Antiviral Res</MedlineTA>
<NlmUniqueID>8109699</NlmUniqueID>
<ISSNLinking>0166-3542</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N">Canada</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Hospital patients</Keyword>
<Keyword MajorTopicYN="Y">Influenza</Keyword>
<Keyword MajorTopicYN="Y">Neuraminidase inhibitor</Keyword>
<Keyword MajorTopicYN="Y">Post-pandemic</Keyword>
<Keyword MajorTopicYN="Y">Predictors</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>11</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>01</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>01</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>2</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>12</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>2</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28179155</ArticleId>
<ArticleId IdType="pii">S0166-3542(16)30612-X</ArticleId>
<ArticleId IdType="doi">10.1016/j.antiviral.2017.01.025</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Canada</li>
</country>
<region><li>Ontario</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Coleman, Brenda L" sort="Coleman, Brenda L" uniqKey="Coleman B" first="Brenda L" last="Coleman">Brenda L. Coleman</name>
</noRegion>
<name sortKey="Green, Karen" sort="Green, Karen" uniqKey="Green K" first="Karen" last="Green">Karen Green</name>
<name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B" last="Gubbay">Jonathan B. Gubbay</name>
<name sortKey="Hassan, Kazi" sort="Hassan, Kazi" uniqKey="Hassan K" first="Kazi" last="Hassan">Kazi Hassan</name>
<name sortKey="Katz, Kevin" sort="Katz, Kevin" uniqKey="Katz K" first="Kevin" last="Katz">Kevin Katz</name>
<name sortKey="Mazzulli, Tony" sort="Mazzulli, Tony" uniqKey="Mazzulli T" first="Tony" last="Mazzulli">Tony Mazzulli</name>
<name sortKey="Mcgeer, Allison J" sort="Mcgeer, Allison J" uniqKey="Mcgeer A" first="Allison J" last="Mcgeer">Allison J. Mcgeer</name>
<name sortKey="Mcneil, Shelly" sort="Mcneil, Shelly" uniqKey="Mcneil S" first="Shelly" last="Mcneil">Shelly Mcneil</name>
<name sortKey="Muller, Matthew" sort="Muller, Matthew" uniqKey="Muller M" first="Matthew" last="Muller">Matthew Muller</name>
<name sortKey="Powis, Jeff" sort="Powis, Jeff" uniqKey="Powis J" first="Jeff" last="Powis">Jeff Powis</name>
<name sortKey="Richardson, David" sort="Richardson, David" uniqKey="Richardson D" first="David" last="Richardson">David Richardson</name>
<name sortKey="Simor, Andrew" sort="Simor, Andrew" uniqKey="Simor A" first="Andrew" last="Simor">Andrew Simor</name>
</country>
</tree>
</affiliations>
</record>

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Pre-and post-pandemic trends in antiviral use in hospitalized patients with laboratory-confirmed influenza: 2004/05-2013/14, Toronto, Canada.

Pre-and post-pandemic trends in antiviral use in hospitalized patients with laboratory-confirmed influenza: 2004/05-2013/14, Toronto, Canada.

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